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Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, such as benzodiazepines and other sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, and alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death

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Mitochondrial cytopathy presents in the neonate as anemia and, in most cases, pancreatic insufficiency (Pearson marrow-pancreas syndrome)

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Some authors noted that in immunocompetent patients, most biopsies showed psoriasiform and pseudoepitheliomatous epidermal hyperplasia with dermal granulomatous inflammation accompanied by varying amounts of necrosis and neutrophilic infiltration