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doi: 10.1038/s41392-023-01640-z 158 FainardiVMeoliAChioprisGMottaMSkenderajKGrandinettiRet al

Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) still in phase 3 trials, whilst tesamorelin is a synthetic GHRH analogue licensed only for HIV-associated lipodystrophy in the US

[Crossref] [Google Scholar] [Pubmed] Li X, Choi JS

Its capacity to promote ATP-dependent drug translocation across the plasma membrane against significant concentration gradients allows it to accomplish this