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Moreover, differences were also registered in the administration of crude resin in comparison to individual compounds, suggesting synergistic pharmacokinetic interactions between constituents

A decreased OCR was also observed in Ndufs4KO mice after addition of ADP (state III), after ATP synthesis inhibition with oligomycin (state IV, proton leak), when the chemical uncoupler FCCP was subsequently injected to induce maximal respiration (state IIIu), and finally when antimycin A was added to assess non-mitochondrial respiration (Supplementary Fig

These findings indicate damage to cell membranes and oxidative stress (Rezayian et al., 2019), resulting from an imbalance between ROS production and the cells antioxidant capacity, impairing metabolic and signaling functions (Yang et al., 2021)

Therefore, hyperhomocysteinemia-induced immunoinflammatory disorders and abnormal immune response may aggravate abnormal immunoinflammatory in PD, leading to more progression of PD severity

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Lactylation and glomerular injury Within the glomerular microenvironment under persistent hyperglycaemic conditions, lactylation exhibits cell-typespecific regulatory characteristics, coordinating metabolic reprogramming with epigenetic and signalling events that collectively drive glomerular injury and filtration barrier dysfunction in diabetic nephropathy