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Conclusion: PI3K/Akt signaling potentially enhanced the expression of immune-escape genes and triggered cytokine secretion, leading to alterations in the immune cell infiltration pattern in HCC recurrence

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Recently, extracellular matrix derived from mesenchymal stem cells were shown to maintain re-differentiation potential of human chondrocytes ( Conclusion In vitro expanding human chondrocytes to a number that is required by the ACI results in the generation of senescent cells