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Chronic ketamine exposure in rodent models (50 mg/kg daily for 8 weeks) leads to significant activation of microglial cells and elevated expression of proinflammatory cytokines, such as IL-6 and IL-1, which correlate with hippocampal neuronal damage (Yin et al., 2022)

The neuropathology data supported the cognitive test results

Batch: GF-NEPI20-B241 Key analytical results include: Assay Content: 22.6 mg Identification Retention Time: 0.991 Identification Spectrum: 994 Purity: greater than 99.8 percent Bacterial Endotoxins: below 0.001 EU per mg Total Aerobic Microbial Count: not detected Total Yeast and Mold Count: not detected Independent heavy metal screening confirmed no detectable levels of arsenic, cadmium, cobalt, lead, nickel, mercury or vanadium

These approaches are mechanistically complementary one adds substrate, the other prevents its degradation