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doi: 10.1007/s00223-020-00735-x, 19

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In recent years, many key molecular mechanisms of ferroptosis have been identified, including GPX4-GSH, ferroptosis-suppressor-protein 1 (FSP1)-CoQ 10 , GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH 4 ), dihydroorotate dehydrogenase (DHODH)-CoQ, and FSP1-vitamin K (VK)[8, 17-19] (Figure 1)

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In contrast, treatment with the same dose of Nano-Bc did not restore the measured parameters to their control values (Fig 6)

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