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Interplay between inflammation and neural plasticity: both immune activation and suppression impair LTP and BDNF expression

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Aberrant DNA methylation in genes regulating immune function, such as FOXP3 and CTLA -4, contributes to altered immune tolerance and disease progression

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We can also do breathing tests, lung function tests, that show that the airflow is obstructed, and that the gas transfer in the lung is also reduced