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Collectively, the ROS are reactive species derived from oxygen that include the superoxide anion (O - ), hydrogen peroxide (H 2 O 2 ), and the hydroxyl radical (OH)

10.1371/journal.pgen.1000004 PLoS Genet

Future studies should continue to explore these important facets of the reproductive aging paradigm in order to better understand their origins and more effectively develop therapeutic options

The increased FAO driven by carnitine leads to an increase in intracellular acetyl-CoA levels, which can be transferred to the nucleus for acetylation of histone H3K27, thereby activating GATA3 gene expression and promoting the differentiation of triple-negative breast cancer cells to the luminal cell state [36]

ICC is a highly heterogeneous tumor, thus research into the molecular profiles and potential pathogenic factors of this tumor is urgently needed

The application of indirect calorimetry in T2DM research has also shed light on the metabolic underpinnings of diabetic complications