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The inflammatory milieu in IBD leads to enhanced ROS generation, causing DNA damage and subsequent 8-OHdG formation (186)

Understanding immunosenescence to improve responses to vaccines

This opens up possibilities for lifestyle interventions to modulate GSH levels and support brain health: ketogenic diets, by generating ketone bodies like -hydroxybutyrate, activate astrocytic Nrf2 signaling to upregulate glutamate cysteine ligase and enhance GSH synthesis