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Semax, a synthetic analogue of the adrenocorticotropic hormone, rapidly elevates brain-derived neurotrophic factor (BDNF) levels, promoting the growth and differentiation of new neurons and synapses in critical brain regions

In parallel, they exert significant immunomodulatory effects: polysaccharides stimulate the immune system's antitumor response by activating macrophages, T lymphocytes, natural killer cells, and dendritic cells, and by promoting the release of cytokines such as TNF-, IFN-, and IL-2 (134)

QSAR quantitative structure-activity relationship D-Nle- Tyr-ile-NH-(CH 2 )5-CONH 2 was predicted to be orally bioavailable

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