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4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions (7)

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For example, page four of the patient brochure includes a presentation regarding the administration of Alymsys by intravenous infusion, but fails to disclose any material information that bevacizumab products, including Alymsys, can cause infusion-related reactions (IRR), including hypertension, hypertensive crises associated with neurologic signs and symptoms, wheezing, oxygen desaturation, Grade 3 hypersensitivity, chest pain, headaches, rigors, and diaphoresis. In addition, the limitations of use are not presented until page four, separate from the information on metastatic colorectal cancer