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Glutathione as a detoxifier We live in a toxic world Glutathione is a critical part of the detoxification process

Interestingly, nitric oxide inhibits mitochondrial respiration by reacting with either the reduced or the oxidized binuclear site of cytochrome c oxidase, leading to ATP depletion

10.1038/s41422-019-0164-5 168 TardioloG.BramantiP.MazzonE

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Since in particular the decrease of reduced thiols (most often glutathione) cannot be mechanistically caused by the same metal-centered mechanism that has been highlighted above for mercury, alternative biologically plausible pathways need to be searched for