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An electrostatic scaffold for the design of newer GLP-1R agonists As mentioned above, the role of charge-charge interactions is only as important as 4.76% (2/42, Table 4 of supplementary file supps.pdf ) in the stabilization of the complex structure of GLP-1R ECD and semaglutide [24], including only two interfacial salt bridges (Table 1) and two interfacial hydrogen bonds (Table 2)