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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

Alternatively, one might imagine that, if an ancestral metazoan evolved a TGR enzyme that could replace both the ancestral TrxR and Gsr activities, as the version does, then perhaps the ancestral type TrxR and the ancestral Gsr were simply and irrevocably lost as being redundant with the new bi-functional TGR enzyme, as seen in

therefore, we tested this hypothesis by exogenous supplementation of uridine