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Although the role of mitochondrial superoxide in erectile dysfunction has not been thoroughly investigated, a potential vasoconstrictive ability has been hypothesized [68], which might contribute to understanding the pathophysiology and be applied in managing ED

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Despite this instability, animal models consistently show that cryptotanshinone produces a more pronounced dose-dependent suppression of the NF-B p65 complex and superior systemic anti-inflammatory outcomes compared to tanshinone IIA (Maione et al., 2018)

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