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The UPR is comprised of three major branches: inositol requiring enzyme 1, protein kinase R-like kinase, and activated transcription factor 6

Hypoxia stress, inflammatory cytokine attacks, delayed revascularization, and lack of nutrients could all contribute to the death of the graft and cause severe related immune reactions

Similar findings are reported in studies in adult pigs and human (195, 196)

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Given the multifaceted nature of AD, there is an urgent need for therapeutic agents capable of targeting multiple pathological pathways (545)

Open pond cultivation is the widespread method used in commercial production of Spirulina due to its relative ease and low cost