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In the adipose tissue of insulin-resistant and obese patients, treatment with selenite was shown to enhance insulin receptor expression in 3T3-L1 pre-adipocytes, improving adipocyte differentiation and function through the induction of GPX3 expression and activation of the transcription factor SP1 [26]

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However, iron chelators have also been shown to inhibit the proliferation of ccRCC cells with VHL dysfunction (81)

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