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This Introduction sets the conceptual framework for the rest of the work and justifies the need for diagnostic and therapeutic strategies that account for source, compartment and context specificity in ROS signaling

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Intracellular G-protein-coupled receptors, particularly the trace amine-associated receptor 1 (TAAR1), function as internal sensors of cytoplasmic catecholamines and their metabolites (Underhill et al., 2021)