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Concurrently, porphyrin-based PDT generates cytotoxic singlet oxygen (O) through energy transfer to molecular oxygen under light activation, triggering apoptosis and autophagy pathways [85, 86]

Validation MR analysis To verify the reliability of our experimental results, we introduced external validation exposures and outcomes

Similarly, pregnant or breastfeeding individuals should avoid use given unknown effects on fetal development

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Exclusion criteria encompassed studies focusing exclusively on the traditional physiological functions of erythrocytes and non-peer-reviewed literature