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In fact, glutathione depletion is linked with a number of disease states and groups: Aging Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer One of the most important things you can do to improve glutathione status is to remove or mitigate stressors that deplete glutathione

Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process

Reduced glutathione: a radioprotector or a modulator of DNA-repair activity

Nakamura, T., Naguro, I

It plays a vital role in maintaining overall health by protecting the body from free radicals and other harmful substances