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Besides eNOS uncoupling, inhibition of the enzyme may also result in a significant drop in vascular NO levels, resulting in endothelial dysfunction and alterations in vascular tone, which may lead to hypertension

doi: 10.3389/fnano.2021.644564

All-cause mortality and cardiovascular outcomes with sodium-glucose Co-transporter 2 inhibitors, glucagon-like peptide-1 receptor agonists and with combination therapy in people with type 2 diabetes

Higher concentrations don't necessarily improve results and may increase irritation risk

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At the 15mg dose, more than half of all participants lost 20% or more of their body weight