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Generally, the oxidation of thiols by ROS enhances channel activity and promotes the efflux of Ca 2+

In the duodenum, pancreatic enzymes degrade the R-protein-B12 complexes, freeing B12 to bind with intrinsic factor (IF) , a glycoprotein produced by gastric parietal cells in the stomach lining

doi: 10.1016/j.rbmo.2023.103319 [DOI] [PubMed] [Google Scholar] 130

Phenomic studies on diseases: Potential and challenges

The execution of ferroptosis involves complex regulation of multiple metabolic pathways (Figure 1), including disruptions in iron homeostasis, abnormalities in amino acid antioxidant systems, and the accumulation of lipid peroxides (Zheng et al., 2025

Metabotropic glutamate receptors: novel targets for drug development