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In dyslexia, specific language-based milestones, such as mastering letter recognition or phonological awareness, are impacted, though general milestones like walking or gross motor skills may be unaffected

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Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority

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The temporal signaling behavior of PT-141 is characterized by a specific onset and peak window within laboratory evaluation settings