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Major challenges in current therapeutic strategies include: Pharmacological options, including antidepressants (duloxetine, milnacipran) and anticonvulsants (pregabalin), primarily target symptom relief without addressing the underlying pathophysiology

These include several strains of inbred mice (young vs

Sydney: NPS

AAPS PharmSciTech 25:61

Limnol Oceanogr Lett

5B) further confirms the moderate correlation (median = 0.14) between gene expression and protein levels, suggesting some divergence between mRNA and protein regulation