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Common B12 deficiency symptoms include: Persistent fatigue and weakness Tingling or numbness in hands and feet Memory problems and difficulty concentrating Mood changes like irritability or depression Dizziness and balance issues Pale skin or yellowing of eyes Sore, red tongue Who is Most at Risk for B12 Deficiency

Phase 2 trials showed 17.5% weight loss at 24 weeks and 24.2% at 48 weeks at the 12mg dose

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All were initially treated with 0.5 mg tesofensine once daily but up-titration to 1.0 mg once daily was allowed in the first 24 weeks of the extension study