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The most studied and controversial target is SLC3A2, which can mediate the export of spermidine, spermine, and putrescine in colonic epithelial cells, as well as the extracellular release of the polyamine metabolic intermediate N1-acetylspermidine in liver cancer cells [290, 291]

Dhner, H

We observed that a decrease in the epithelial marker cadherin 1 (CDH1) (Supplementary 5A,B) and a significant increase in mesenchymal markers like smooth muscle actin (ACTA2) and Vimentin, particularly in the TC THP1 model, indicating enhanced EMT in response to CS exposure (Supplementary Fig

Reduced mitochondrial respiration and ATP production has been reported in Cln3 ex7/8 murine astrocytes, both under resting conditions and upon exposure to proinflammatory cytokines [46]

N., Paull, J

These new carrier systems can intelligently release drugs according to changes in the physiological environment in the body, increasing the concentration of the drug in the target tissue (182)