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Second, in latently infected macrophages the metabolic steps in the tricarboxylic acid (TCA) cycle preceding oxidative phosphorylation (OXPHOS) were compromised, resulting in lipid accumulation, which is typically observed in several tissues and cells in the HIV infected population 18,19

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AATF protein contains three serine/threonine-glutamine (S/T-Q) motifs at its residues Ser189, Thr394, and Thr410, which are the potential phosphorylation sites for kinases involved in activating DNA damage responses, including ATM, ATR, and DNA-PKcs 32,33

In conclusion, the evidence suggests that IST-induced covalent oligomerization of p62 to activate Nrf2 may represent a promising avenue for the treatment of RA [132]