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Known as the master antioxidant, glutathione is naturally produced in the bodybut levels decrease with age, stress, and environmental toxins

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thaliana with the BLAST tool, and searched GhGPX9, 10 from another database ( The GhGPX genes were amplified by PCR (Fast Pfu DNA polymerase, Novoprotein) and the primers used for cloning and analysing the full-length CDS of GhGPX genes were designed by using Primer Premier 5 and their sequences were listed in Supplementary Table S1

These results indicated that the Pro198Leu polymorphism in GPx1 and the associated LOH are factors of significance in breast cancer development