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Flagg EW, Coates RJ, Eley JW, Jones DP, Gunter EW, Byers TE et al

During intestinal inflammation, TJs show strand breaks, and changes in TJ proteins composition and function as well as impaired structure and remodeling of apical junctions (213)

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Gastroenterology 2003

Resistant BT16 cells not only were observed to have higher basal levels of GSH, but also higher basal expression levels of Nrf2

For instance, longitudinal scRNA-seq studies in high-grade serous ovarian carcinoma revealed that residual tumor cells adopt stress-response transcriptional states that may pre-dispose them to later resistance [21]