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Drugs administered by IN penetrate through the nasal epithelial barrier, followed by diffusion into the perivascular or perineural spaces, and finally throughout the brain though some of the drug will be lost by entering the lymphatic and systemic blood circulation [12]

Writing original draft: AC, AW, SN-L, and LP

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Novo Nordisk has already filed for FDA approval of CagriSema based on these results

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Importantly, glycolysis represents a central hub of cellular energy metabolism, tightly linked to ATP production, redox balance, and biosynthetic processes