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The fact that exogenous melatonin applied into the seeds affects not only the activity but also genetic expression of antioxidant enzymes such as SOD and GSSG-R, generating their additional isoforms is the crucial finding of the presented research

The ability of selenomethionine to resist ferroptosis is preserved in GPX4-deficient cells Our findings suggest that selenomethionine can provide selenium to cells through alternative metabolic pathways beyond the canonical transsulfuration pathway

Se compounds can exert cytotoxic effects by acting as pro-oxidants that alter cellular redox homeostasis, eventually leading to apoptosis induction in many kinds of cancer cells