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This has a widespread deacetylase activity, with a variety of targets including histone, tumor suppressor P53, fork transcription factor (FOXO), DNA repair protein Ku70, peroxisome proliferator-activated receptor (PPAR) and nuclear transcription factor-B (NF-B) (83)

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[59] demonstrated that TCA disorders led to the down-regulation of succinate dehydrogenase (SDH) and fumarate hydratase (FH) activities, which resulted in the accumulation of succinate, PHD activity inhibition, and HIF-1 induction

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At 3d of drought stress, ROC22 enriched more photosynthesis- and oxidative activity-related terms, while ZZ2 and ZZ9 enriched more terms related to oxidative activity, plant hormones, polysaccharide synthesis, and flavonoid biosynthesis

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