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[20] Patients should contact their GP or bariatric team promptly if they experience any of the following: New or worsening tingling, numbness, or weakness in the limbs Difficulty with balance, coordination, or memory Unexplained fatigue, breathlessness, or palpitations A sore or swollen tongue, or persistent mouth ulcers Any concern that they have missed supplementation for a prolonged period Symptoms that suggest anaemia, such as pallor or dizziness New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change warrant same-day assessment

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A deep ache in the low back or hip that travels down the leg

You can, but night dosing reduces bioavailability by 3540% compared to morning fasted-state administration

In murine models, NNMT knockdown did not induce the accumulation of NAM in livers and adipose tissues, nor did it cause significant alterations in the intracellular levels of NAD + in hepatocytes (Kraus et al., 2014

Delivers the vitamin directly into the tissue, bypassing the gut entirely