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Kotas ME, Medzhitov R

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Hayashi, FDA, Christopher Koh, National Institute of Diabetes and Digestive and Kidney Diseases, Nih, Jose Serrano, National Institute of Diabetes, Bethesda, MD, United States, Averell H

Herein, we identify unique temporal expression patterns of Hb-a1 mRNA and Hb protein in both CD4 + and CD8 + T-lymphocytes, with the loss of Hb in T-lymphocytes exhibiting a decrease in mitochondrial metabolism, increase in proinflammatory cytokine production after 24-hour activation, and a decreased threshold for activation compared to wild-type (WT) T-lymphocytes

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