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Mass spectrometry analysis of metabolitesinstrumental condition and data analysis For the mass spectrometry analysis of metabolites, the previously established LC-MS conditions were applied 99

The combination of DHA with cisplatin triggered cell death in pancreatic ductal adenocarcinoma (PDAC) by promoting the degradation of GPX4, creation of ROS and the degradation of ferritin, leading to induction of ferroptosis (Du J