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STUB1 plays a central role in protein quality control by linking molecular chaperones to the UPS, playing a critical role in proteostasis (VanPelt and Page, 2017)

Excess Cu + /Cu 2+ and Fe 2+ /Fe 3+ promote the production of reactive hydroxyl radicals through the Fenton reaction, leading to permanent modifications of cellular lipids, nucleic acids, and proteins and causing oxidative damage and cell death (155)

15, 16 Primary antibodies to mouse K14 (ab7800, 1:500), p63 (ab53039, 1:100), PCNA (ab29, 1:200) and cleaved Caspase3 (ab13847, 1:100) were purchased from Abcam

Nanotechnology has received a great attention as it can resolve problems linked to the conventional therapeutic agents, such as lack of targeting capability, poor water solubility, systemic toxicity, and nonspecific distribution (Sreelakshmi et al., 2018)

More recently, the SARS-CoV-2 protein ORF7a has been shown to interact with CD14 + monocytes, triggering downmodulation of HLA-DR and production of proinflammatory cytokines in vitro (63)

The elevated ratio of CSF/serum albumin and reduced expression of BSCB TJs proteins has been reported in both forms of this disease [110]