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In psychiatric disorders, abnormalities of melatonin secretion and regulation have been reported [7, 8]

Animals were included in experiments at 8 weeks of age with randomization into different experimental groups without blinding

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315 Notably, although tenofovir disoproxil fumarate treatment can significantly alter the gut flora of HBV-infected individuals, it failed to fully restore it to a healthy state, and serum inflammatory cytokine concentrations did not improve significantly, suggesting that treatment duration may affect flora recovery and inflammation remission