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Summary Keywords chronic stress, cognitive dysfunction, hippocampus, hypothalamic-pituitary-adrenal axis, myalgic encephalomyelitis/chronic fatigue syndrome Citation Kang H, Shao T, Shi Y, Wang S, Xiong H, Jin X and Ren J (2026) Chronic stress and cognitive dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: HPA axis dysregulation and hippocampal plasticity

In particular, cocaine treatment in mice has been shown to cause a bidirectional loss of activity-dependent synaptic plasticity in the nucleus accumbens core, which is a defect in both LTP and LTD of excitatory synaptic transmission [114]

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