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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

B12 is a vitamin that plays a crucial role in cognitive and nervous system functions

Research applications: NNMT activity assays, NAD/SAM metabolism studies, adipocyte energy-expenditure models

The gut-brain axis is complex, and altering gut hormone signaling can have downstream effects on neurotransmitter systems that influence mood and emotional regulation

NNMT inhibition addresses the deficit by preventing the enzyme (NNMT) that wastes the precursor from inside the cell

Their efficacy has not been confirmed by FDA-approved research, and they are not intended to diagnose, treat, cure, or prevent any disease