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ICH harmonised guideline: S2(R1) Genotoxicity testing and data interpretation for pharmaceuticals intended for human use (Current Step 4 version)

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A potential role for a secretory granule-associated ARF6 protein

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The PINK1/Parkin pathway is activated on depolarized mitochondria, often as a consequence of oxidative damage, and its activation is facilitated by fission, which generates isolated, damage-susceptible organelles

This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients