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177,179181 Like vitamin C, hesperidin exerts its anti-inflammatory effect by inhibiting the NF-B signaling pathway and reducing inflammatory cytokines, such as TNF-, IL-6, and IL-1

In practice, that same additive quality is also the main risk: two strong satiety agents together can suppress appetite and slow the gut more than intended, which is why tolerability not maximum weight effect tends to be the limiting factor in any amylin-plus-incretin discussion

Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G

Dodson M, Darley-Usmar V, Zhang J

NakamuraKYaguchiTOhmuraGKobayashiAKawamuraNIwataTet alInvolvement of local renin-angiotensin system in immunosuppression of tumor microenvironment

In any case, you should follow the medical advice of licensed physicians