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Chemotherapy and radiotherapy Chemotherapy and radiotherapy are routine clinical treatments

The effects of n-methyl butyrohydroxamic acid and other monohydroxamates on reperfusion-induced damage to contractile function in the isolated rat-heart

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For example, Lee et al (97) demonstrated that hydrogen peroxide can oxidize cysteine residues in PTEN, forming a disulfide bond between Cys124 and Cys71, leading to PTEN inactivation

46 In post-transplant patients, immunosuppression leads to repression of T-cells with a subsequent uncontrolled proliferation of lymphoid cells

In non-small cell lung cancer, EAAT3 overexpression facilitates recycled extracellular glutamate into the cells by enhancing xCT activity and the consequent GSH biosynthesis to favor tumor growth and a malignant phenotype (188)