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Senescence markers, such as p16, p21 and SASPs, are increased in NRF2-deficient mice (Liu et al., 2019) and up-regulation of pro-inflammatory factors, such as NF-B (Stockler-Pinto et al., 2018)

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Related reading: This article was originally published in July 2021, written by Krystina Martinez

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Allograft matrices encourage the formation of hyaline-like cartilage, which is closer to the native cartilage structure compared to fibrocartilage

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The monoclonal antibody Mab5G9, which blocks TF-VIIa-mediated activation of PAR-2 and disrupts the interaction of TF with integrins, has also shown antineoplastic activity in breast cancer preclinical models [121]

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