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Upregulation of TIGAR reduces BNIP3 activation by inhibiting ROS signal (Hoshino et al., 2012)

Fast-forward through my medical residency at Albert Einstein College of Medicine, when I had a ward rotation on the general clinical research center where I saw a number of these patients

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Voice rest serves to reverse swelling associated with phonotrauma and can help restore baseline voice, but hoarseness will recur the next time the voice is used strenuously unless underlying patterns of voice use change