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Studies have consistently demonstrated the therapeutic and biological effects of berberine through the activation of the Nrf2 pathway [62]

Biochem Biophys Res Commun 501:365373

Simpson RW, Nicholson GC, Proietto J, Sarah A, Sanders KM, Phillips G, et al

Sovio U, Gaccioli F, Cook E, Hund M, Charnock-Jones DS, Smith GCS (2017) Prediction of preeclampsia using the soluble fms-like tyrosine kinase 1 to placental growth factor ratio: a prospective cohort study of unselected nulliparous women

This molecule, and related compounds, possesses two very reactive electrophilic sites: the aldehyde group and the alkene bond

Owing to the downregulation of IDH expression and the upregulation of the expression of the mitochondrial citrate carrier (CIC), M1 macrophages characteristically accumulate citrate, which is then transported out of the mitochondria (112)