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Instead, there is a clear need to aggressively optimize medical therapy which represents one potentially modifiable variable to offset the multiplicity of negative cofactors associated with active smoking status that likely have a detrimental role in the course and severity of IBD, yet are not so easily modifiable, including socioeconomic and educational status, dietary behaviors and medication (non)adherence

Stefanelli T, Malesci A, Repici A, Vetrano S, Danese S

Advertisements that appealed to doctors' endorsements continued into the 1940s