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Wu CC, Beird HC, Andrew Livingston J, Advani S, Mitra A, Cao S, et al

Mechanistically, SQOR preserves intestinal homeostasis through two major pathways: it inhibits Drp1-mediated mitochondrial fission, thereby reducing ROS accumulation, and it activates the PGC1 pathway to promote mitochondrial biogenesis and antioxidant defenses (upregulating enzymes like GPX4 and SOD2)