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Approval of Enzeevu was granted based on the totality of evidence, including comprehensive analytical and preclinical in vitro study data, in addition to clinical data from the Mylight study, which showed equivalent efficacy, safety and immunogenicity to Eylea, according to Sandozs press release

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We observed that addition of electron-withdrawing substituents on the phenyl ring increased the electrophilicity of the chloroacetamide carbon and improved potency of inhibition (Supplementary Table 1)

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Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression)

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