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In another study dietary AOx supplementation with vitamin C and E (VCE) and the combination of vitamin C, E and Nacetylcysteine (NAC) (Comb) significantly modulated OS and accelerated wound closure rates in diabetic mice compared to controls, with noticeable improvements beginning as early as day 2 postwounding

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Abbreviations ADP adenosine diphosphate ATP adenosine triphosphate CEACAM-1 carcinoembryonic antigen-related cell adhesion molecule 1 cGMP cyclic guanosine monophosphate CKD chronic kidney disease CV cardiovascular DKD diabetic kidney disease DNL de novo lipogenesis eGFR estimated glomerular filtration rate ENaC epithelial sodium channel ER endoplasmic reticulum FFA free fatty acid FoxO1 forkhead box O1 GBM glomerular basement membrane GIT glutathione-insulin transhydrogenase GLUT1 glucose transporter 1 GLUT2 glucose transporter 2 GLUT4 glucose transporter 4 GRB2 growth factor receptor-bound protein 2 GSK3 glycogen synthase kinase 3 GSV GLUT storage vesicle IDE insulin-degrading enzyme INSR insulin receptor IR insulin resistance IRS1 insulin receptor substrate 1 IRS2 insulin receptor substrate 2 MAPK mitogen activated protein kinase mTOR mammalian target of rapamycin NAFLD non-alcoholic fatty liver disease NBCe1 sodium bicarbonate cotransporter 1 NHE-3 sodium/hydrogen exchanger 3 NKCC2 sodium-potassium chloride cotransporter-2 PGC1 peroxisome proliferator-activated receptor- coactivator 1 PI3K phosphatidylinositol 3-kinase PIP2 phosphatidylinositol 4,5 biphosphate PIP3 phosphatidylinositol 3,4,5 triphosphate PKB protein kinase B PKG cGMP-dependent protein kinase G PKGI cGMP-dependent protein kinase G isoform I PPAR peroxisome proliferator-activated receptor PT proximal tubule PTEN phosphatase and tensin homolog PTP1B protein tyrosine-phosphatase 1B SGK1 serum/glucocorticoid regulated kinase 1 SGLT sodium-glucose transport proteins SGLT2 sodium-glucose co-transporter 2 SGLT2i sodium-glucose co-transporter-2 inhibitors SHIP2 SH2-domain-containing inositol phosphatase 2 SREBP-1c sterol regulatory element binding protein-1c T1DM type 1 diabetes mellitus T2DM type 2 diabetes mellitus TZDs thiazolidinediones Vamp2 vesicle-associated membrane protein 2

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These lenses offer the potential to enhance bioavailability and reduce the frequency of administration, enabling prolonged release of pharmaceuticals (237, 238)