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Neuroendocrine Regulation Corticotropin, LH, and GH DSIP reduces basal corticotropin (ACTH) levels a consistently replicated finding across multiple studies and stimulates secretion of luteinising hormone (LH) and the release of somatotropin (GH) and somatoliberin (GHRH)

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10.1111/j.1399-3054.2008.01097.x 38 GamaF.KeechO.EymeryF.FinkemeierI.GelhayeE.GardestrmP.et al

FIGURE 7 Measurement of adipokines as adiponectin and leptin in PPAT samples showed that PWE co-treatment was able to increase adiponectin levels in PPAT compared to testosterone alone, indicating a shift toward a more anti-inflammatory and metabolically favorable adipose profile

The approval was backed by data from the Phase II TRANSCEND FL study in which treatment with the CAR T cell therapy led to a 95.7% overall response rate, with a complete response rate of 73.4%